Personal ventilation systems supply fresh air directly into breathing zone. This systems have a big potential in creating good indoor air quality in the breathing zone and should minimise cross infection risk between occupants. Its particular applications are in office buildings where people most of the time people spend in a sitting position. People can easily adjust ventilation parameters (air flow rate) to their needs. Following tendency in reduction of energy use in buildings, personal ventilation systems can be considered as a good alternative comparing to other ventilation systems which can reduce energy consumption while keeping high quality of indoor air. The aim of the study is analysis of the optimal solution in terms of energy consumption and indoor air quality for personal ventilation. Performance of the personal ventilation systems alone and supported with additional systems was analysed. It was examined whether personal ventilation can act as an independent source of fresh air in the room and whether it is sufficient to maintain a satisfactory quality of the room both at the workplace and in the entire people zone. Experimental analysis performed previously in climatic chamber for different combination of installed ventilation systems were used as a boundary and initial conditions in the numerical model. Three of them were chosen for the validation of the numerical model: Total volume mixing ventilation (TVMV), Chilled ceiling combined with mixing ventilation (CCMV) and Chilled ceiling combined with personal ventilation (CCPV). Additional chilled ceiling in that case is used to remove heat load generated in the space. Three dimensional numerical model of climatic chamber arranged as an office with two workstation was built in Workbench Ansys. At each workstation one thermal manikin was placed. One of the manikin was a breathing manikin referred as a “polluting manikin”. Air exhaled by this manikin was marked with SF6 which simulated exhaled contaminants like bacteria and viruses. The chamber was equipped with mixing ventilation and ceiling chilling systems as well with personal ventilation on each desk. Round movable panels were used as a personal diffusers in order to provide high efficiency in clean air delivered to occupants.